Peer-Reviewed Publication
Respir Med2026;259108911.August 1, 2026Journal Article
Guidance for chest-CT in children and adults with cystic fibrosis: A European perspective (part 2: special situations/respiratory complications).
Michael Fayon1, Kate Hill2, Luca Riberi3, Gael Dournes4, Pierre-Régis Burgel5, Barbara Messore3, Michael Waldron6, Marcus Svedberg7, Elise Lammertyn8, Stojka Fustik9, Andrea Gramegna10, Mirjam Stahl11, Anna Kerpel-Fronius12, Maurizio Balbi13, Pierluigi Ciet14, Guillaume Chassagnon15, Cinzia Ferrero16, Sivagurunathan Sutharsan17, Marcel Opitz18, Eleni-Rosalina Andrinopoulou19, Michael Maher6, Jamie Duckers20, Harm Tiddens21, Isabelle Sermet-Gaudelus22
1CHU Bordeaux, Département de Pédiatrie, CIC-P INSERM 1401 & Université de Bordeaux, Centre de Recherche Cardio-thoracique de Bordeaux, INSERM U1045, Bordeaux, F-33000, France.
2European Cystic Fibrosis Society, Karup, Denmark; Northern Ireland Clinical Research Facility, The Wellcome-Wolfson Institute of Experimental Medicine, Queen's University, Lisburn Road, Belfast, the Netherlands. Electronic address: kate.hill@qub.ac.uk.
3AOU San Luigi Gonzaga, Adult CF Centre-Pulmonology Unit, Orbassano-Torino, Italy.
4Univ. Bordeaux, INSERM, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, Pessac, F-33600, France.
5Department of Respiratory Médicine and National Cystic Fibrosis Reference Centre, Groupe Hospitalier Cochin-Hôtel Dieu, AP-HP, Université Paris Cité and Institut Cochin, Inserm U1016, 27 Rue du Faubourg Saint-Jacques, Paris, 75014, France.
6Cork Centre for Cystic Fibrosis, Cork University Hospital, University College Cork, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland; Department of Radiology, Cork University Hospital, Cork, Ireland.
7Department of Pediatrics, Institute of Clinical Science at The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, Queen Silvia's Children Hospital, Gothenburg, Sweden.
8Cystic Fibrosis Europe, Belgium and the Belgian CF Association, Brussels, Brussels, Belgium.
9Center for Cystic Fibrosis, University Children's Clinic, Skopje, North Macedonia.
10Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
11Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.
12Department of Radiology, National Korányi Institute for Pulmonology, Budapest, Hungary.
13Radiology Unit, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy.
14Department of Paediatrics, Division of Respiratory Medicine and Allergology, Sophia Children's Hospital, Erasmus MC, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
15Department of Radiology, Hôpital Cochin, AP-HP, Université Paris Cité, 27 Rue du Faubourg Saint-Jacques, Paris, 75014, France.
16AOU Città della Salute e della Scienza di Torino, Regina Margherita Children's Hospital - Pediatric Pulmonology/Pediatric CF Centre, Torino, Italy.
17Department of Pulmonary Medicine, University Hospital Essen - Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Essen, Germany.
18Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
19Department of Biostatistics, Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands; Statistics and Data Science Innovation Hub, GSK, Amsterdam, the Netherlands.
20All Wales Adult CF Centre, Cardiff and Vale University Health Board, Cardiff, UK.
21Thirona, Nijmegen, the Netherlands.
22Service de Pneumologie et Allergologie Pédiatriques, Centre de Référence Maladies Rares, Hôpital Necker Enfants Malades, Paris, 75015, France; INSERM U1151, Institut Necker Enfants Malades, Université Paris Cité, Paris, 75743, France; European Reference Network-Lung., Frankfurt, Germany.
Abstract
This manuscript covers guidance proposed by The European Cystic Fibrosis Society Clinical Trials Network (ECFS-CTN) for the use of chest computed tomography (CT) scans in special situations such as haemoptysis, aspergillus-related lung disease, non-tuberculous mycobacterial (NTM) infection and pneumothorax in people with CF. Guidance development followed a three-step process. The most important qu…
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