Characterizing the Activity of Inflammasome-Related Genes and Their Association With Oncological Outcomes in Prostate Cancer.

Alireza Ghoreifi¹, Mohammed Alshalalfa², Elai Davicioni², Daniel E Spratt³, R Jeffrey Karnes⁴, J Todd Purves¹, Francis M Hughes¹, Judd W Moul¹, Michael R Abern¹

¹Department of Urology, Duke University, Durham, North Carolina, USA.

²Veracyte, Inc, South San Francisco, California, USA.

³Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Cleveland, Ohio, USA.

⁴Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.

PubMed DOI

Abstract

BACKGROUND: Inflammation plays a critical role in cancer cell proliferation; however, the specific role of inflammasomes, multiprotein complexes that regulate inflammation-associated signaling pathways, in prostate cancer (PCa) remains insufficiently explored. This study aims to characterize the expression of inflammasome-related genes in PCa and evaluate their association with clinical outcomes.…

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