Early detection of pulmonary mucormycosis using microbial cell-free DNA sequencing of bronchoalveolar lavage fluid in neutropenic Hosts: A report of two cases.

Yupeng Liu¹, Julia S Zinn², Kevin M Grudzinski³

¹Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

²Medical Science Liaison, Karius Inc, Redwood City, CA, United States.

³Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

PubMed PMC DOI PDF

Abstract

Mucormycosis is an aggressive fungal infection characterized by angioinvasion, tissue necrosis, and high mortality rates. Microbial cell-free DNA (mcfDNA) sequencing provides rapid, non-invasive detection of microbial genetic material to guide diagnosis and treatment. We describe 2 cases of immunocompromised patients with invasive mucormycosis wherein mcfDNA sequencing significantly expedited diag…

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