Differential cerebral white matter tract alterations in generalized anxiety disorder revealed by ultra-high-field 7 T diffusion-weighted imaging.

Chang-Le Chen¹, Minjie Wu², Yueyang Chi², Max Rose¹, Jessica C Weber¹, Shannon T Lamb¹, Hecheng Jin³, Tamer S Ibrahim³, Cecile D Ladouceur², Yue-Fang Chang⁴, Kuei Y Tseng⁵, Howard J Aizenstein¹, Shaolin Yang⁶

¹Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

²Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

³Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

⁴Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.

⁵Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.

⁶Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: yans@pitt.edu.

PubMed DOI

Abstract

Generalized anxiety disorder (GAD) is characterized by chronic worry and emotional dysregulation, yet its underlying white matter (WM) microstructural alterations remain unclear owing to inconsistent findings and technical limitations in prior neuroimaging studies. To address this gap, we employed ultra-high-field 7-Tesla (7 T) diffusion tensor imaging (DTI) and advanced correlational tractography…

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