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Clin Gastroenterol Hepatol2026May 20, 2026Journal Article

Hepatic Steatosis Is Associated With Increased Cardiovascular Risk Through Adverse Coronary Plaque Composition.

Jan M Brendel1, Thomas Mayrhofer2, Nóra M Kerkovits3, Márton Kolossváry4, Sara Ersözlü5, Brooke Alhanti6, Kathleen E Corey7, Neha Pagidipati8, Svati H Shah8, Nandini M Meyersohn9, Maros Ferencik10, Michael T Lu9, Stefania Lamon-Fava11, Udo Hoffmann12, Pamela S Douglas8, Borek Foldyna13
1Department of Radiology, Cardiovascular Imaging Research Center (CIRC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Radiology, University of Tuebingen, Tuebingen, Germany.
2Center for Preventive Medicine and Digital Health, University of Heidelberg, Mannheim, Germany.
3Department of Radiology, Cardiovascular Imaging Research Center (CIRC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
4Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Gottsegen National Cardiovascular Center, Budapest, Hungary; Physiological Controls Research Center, University Research and Innovation Center, Óbuda University, Budapest, Hungary.
5Department of Radiology, Cardiovascular Imaging Research Center (CIRC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland; Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.
6Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina.
7Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
8Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
9Department of Radiology, Cardiovascular Imaging Research Center (CIRC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
10Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
11Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts; Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts.
12Cleerly Inc., Denver, Colorado.
13Department of Radiology, Cardiovascular Imaging Research Center (CIRC), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: bfoldyna@mgh.harvard.edu.
PubMed DOI

Abstract

BACKGROUND & AIMS: Hepatic steatosis has been associated with major adverse cardiovascular events independently of other cardiovascular risk factors and the severity of coronary artery disease. Nevertheless, the relationship between hepatic steatosis, coronary plaque composition, and major adverse cardiovascular events remains unclear. METHODS: A central core laboratory analyzed Prospective Multi…

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