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Peer-Reviewed Publication
Nat Commun2026;17(1)May 20, 2026Journal Article

Multi-modal AI for comprehensive breast cancer prognostication.

Jan Witowski1, Ken G Zeng1, Joseph Cappadona1, Jailan Elayoubi2, Khalil Choucair2, Elena Diana Chiru3, Nancy Chan4, Young-Joon Kang5, Frederick Howard6, Irina Ostrovnaya7, Carlos Fernandez-Granda8,9, Freya Schnabel4, Zoe Steinsnyder1, Ugur Ozerdem4, Kangning Liu8, Waleed Abdulsattar2, Yu Zong2, Lina Daoud2, Rafic Beydoun2, Anas M Saad2, Nitya Thakore4, Mohammad Sadic4, Frank Yeung4, Elisa Liu4, Theodore Hill4, Benjamin Swett4, Danielle Rigau4, Andrew J Clayburn4, Valerie Speirs10, Marcus Vetter3, Lina Sojak3, Simone Muenst11, Daniel Baumhoer11, Jia-Wern Pan12, Haslina Makmur12, Soo-Hwang Teo12, Linda M Pak4, Victor Angel13, Dovile Zilenaite-Petrulaitiene14, Arvydas Laurinavicius14, Natalie Klar4, Brian D Piening15, Carlo Bifulco15, Sun-Young Jun5, Jae Pak Yi5, Su Hyun Lim5, Adam Brufsky16, Francisco J Esteva17, Lajos Pusztai18, Yann LeCun8,9,19, Krzysztof J Geras20,21,22
1Ataraxis AI, New York, NY, USA.
2Karmanos Cancer Institute, Detroit, MI, USA.
3Cancer Center Baselland, Basel, Liestal, Switzerland.
4NYU Grossman School of Medicine, New York, NY, USA.
5The Catholic University of Korea, Seoul, South Korea.
6UChicago Medicine, Chicago, IL, USA.
7Memorial Sloan Kettering Cancer Center, New York, NY, USA.
8NYU Center for Data Science, New York, NY, USA.
9NYU Courant Institute of Mathematical Sciences, New York, NY, USA.
10The University of Aberdeen, Aberdeen, Scotland.
11University Hospital Basel, Basel, Liestal, Switzerland.
12Cancer Research Malaysia, Subang Jaya, Malaysia.
13Omica.bio, Mexico City, Mexico.
14Vilnius University, Vilnius, Lithuania.
15Providence Health, Renton, Washington, US.
16University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
17Northwell Health, New York, NY, USA.
18Yale School of Medicine, New Haven, CT, USA.
19Meta AI, New York, NY, USA.
20Ataraxis AI, New York, NY, USA. krzysztof.geras@nyulangone.org.
21NYU Grossman School of Medicine, New York, NY, USA. krzysztof.geras@nyulangone.org.
22NYU Center for Data Science, New York, NY, USA. krzysztof.geras@nyulangone.org.
PubMed PMC DOI PDF

Abstract

Treatment selection in breast cancer is guided by risk assessment using molecular subtypes and clinicopathological characteristics. However, current approaches lack the precision required for optimal clinical decision-making. To address this, we use data from 8161 patients to develop and evaluate an AI test integrating digital pathology with clinical data. The AI test provides a robust method for…

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