Accelerated deficit accumulation in frailty and associations with adverse outcomes: a longitudinal population data analysis.

Lara Johnson¹, Bruce Guthrie¹, Atul Anand², Alan Marshall³, Sohan Seth⁴

¹Advanced Care Research Centre, University of Edinburgh, Edinburgh, UK.

²Advanced Care Research Centre, University of Edinburgh, Edinburgh, UK; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

³Advanced Care Research Centre, University of Edinburgh, Edinburgh, UK; School of Social and Political Science, University of Edinburgh, Edinburgh, UK.

⁴Advanced Care Research Centre, University of Edinburgh, Edinburgh, UK; School of Informatics, University of Edinburgh, Edinburgh, UK. Electronic address: sohan.seth@ed.ac.uk.

PubMed DOI

Abstract

BACKGROUND: Frailty, reflecting increased vulnerability to adverse outcomes, is commonly measured by the accumulation of health deficits. We aimed to determine whether periods of accelerated deficit accumulation involve specific deficits and whether these periods provide additional prognostic value for adverse outcomes beyond total deficit count. METHODS: In this longitudinal cohort study, we ana…

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