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Peer-Reviewed Publication
Angew Chem Int Ed Engl2026;65(27):e8964304.July 1, 2026Journal Article

A Unified Radical C-SuFEx Platform via Catalytic EDA Complex-Mediated S(VI)─F Bond Activation.

Ting Xiong1, Ya-Qi Wang1, Zi-Jun Hu1, Lu Tan2, Zhi-Bing Hao1, Feng-Bin Wu1, Jing Guo2, Gui Lu1, Jiang Weng1
1State Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China.
2XtalPi Inc. (Shenzhen Jingtai Technology Co., Ltd.), Shenzhen, China.
PubMed DOI

Abstract

Sulfur(VI) Fluoride Exchange (SuFEx) chemistry has emerged as a powerful tool for forging diverse molecular architectures. While sulfur(VI) fluorides are typically employed as S(VI)+ electrophiles in defluorinative reactions with heteroatom nucleophiles, the direct formation of S(VI)─C bonds via C-SuFEx processes remains a significant challenge and is largely underdeveloped. Herein, we report a ge…

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