Combined Oral Contraceptives and Stroke Risk in Individuals With Migraine With Aura.

Liza R Gibbs¹, Matthew P Fox, Hugo J Aparicio, Susan Jick

¹Department of Epidemiology, Boston University School of Public Health, and the Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, and the Boston Collaborative Drug Surveillance Program, Lexington, Massachusetts; and Aetion, a Datavant Company, New York, New York.

PubMed DOI

Abstract

OBJECTIVE: To estimate the effect of combined oral contraceptives (COCs) compared with non-estrogen-containing oral contraceptives on the risk of stroke among individuals with migraine with aura. METHODS: Using U.K. primary care medical records with linked hospital data from the Clinical Practice Research Datalink, the authors evaluated the risk of stroke associated with use of COCs, containing e…

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