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Peer-Reviewed Publication
Radiol Cardiothorac Imaging2026;8(3):e240525.June 1, 2026Journal Article

Prediction of Anthracycline-induced Cardiotoxicity Using Cardiac MRI Parameters: An Animal Study.

Na Young Kim1, Jinho Park2, Heae Surng Park3, Yoonjung Kim4, Ji Won Kim5, Jung Im Jung6, Eun-Ju Kang7, Kyunghwa Han1, Chul Hwan Park5, Peder E Z Larson8, Yoo Jin Hong1
1Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2Phantomics Co, Ltd, Seoul, Republic of Korea.
3Department of Pathology, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea.
4Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
5Department of Radiology, Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
6Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
7Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.
8Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif.
PubMed DOI

Abstract

Purpose To evaluate the prognostic utility of cardiac MRI parameters, particularly native T1 and extracellular volume fraction (ECV), for predicting early mortality in a preclinical model of anthracycline-induced cardiotoxicity. Materials and Methods Thirty-one Sprague-Dawley rats received weekly intravenous doxorubicin injections (2 mg/kg) for up to 12 weeks and were followed up until natural dea…

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