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Peer-Reviewed Publication
bioRxiv2026May 5, 2026Journal Article

Linking human brain functional connectivity to underlying neurotransmission.

Leon D Lotter1,2,3, Golia Shafiei4,5,6, Daouia Larabi7, Abhay Koushik3,8, Ottavia Dipasquale9, Mitul Mehta10, Mara Cercignani11, Arjun Sethi10, Neil Harrison11, Štefan Holiga12, Daniel Umbricht13, Igor Yakushev14, Suresh Muthukumaraswamy15, Anna Forsyth15, Joerg F Hipp12, Bratislav Misic16, Svenja Caspers17,18, Julian Koenig19, Kaustubh R Patil1,2, Casey Paquola1,2, Simon B Eickhoff1,2, Juergen Dukart1,2
1Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich; Jülich, Germany.
2Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf; Düsseldorf, Germany.
3Max Planck School of Cognition; Stephanstrasse 1A, Leipzig, Germany.
4Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.
5Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
6Lifespans Brain Institute (LiBI), Children's Hospital of Philadelphia and Penn Medicine; Philadelphia, PA, USA.
7Department of Clinical and Developmental Neuropsychology, University of Groningen; Groningen, the Netherlands.
8Max Planck Institute for Human Cognitive and Brain Sciences; Stephanstr. 1A, Leipzig, Germany.
9Olea Medical; La Ciotat, France.
10Institute of Psychiatry, Psychology, and Neuroscience, King's College London; London, UK.
11Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University; Cardiff, UK.
12Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd; Basel, Switzerland.
13Xperimed LLC; Basel, Switzerland.
14Department of Nuclear Medicine, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich; Munich, Germany.
15School of Pharmacy, University of Auckland; NZ.
16Montreal Neurological Institute, McGill University; Montreal, QC, Canada.
17Institute for Anatomy I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf; Düsseldorf, Germany.
18Institute of Neurosciences and Medicine (INM-1), Research Centre Jülich; Jülich, Germany.
19University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy; Cologne, Germany.
PubMed PMC DOI PDF

Abstract

The human brain is organized into interacting functional systems. Their underlying neurobiological mechanisms remain difficult to study in vivo1,2. Here, we adopt a topological framework to quantify the association between neurobiology and brain functional connectivity derived from both resting-state functional magnetic resonance imaging (rsfMRI) and magnetic encephalography (MEG). Across six heal…

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