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Am J Surg Pathol2026April 21, 2026Journal Article

Enteroblastic and Hepatoid Colorectal Carcinomas are Aggressive Cancers With a Distinctive Immunophenotype, While Clear Cell Carcinoma Appears to Represent Clear Cell Change in Conventional Colorectal Cancer.

Fahad Khan1, Alexandros D Polydorides2, John D Paulsen2, Wei Chen3, Jennifer Vazzano3, Aaron Huber4, David Papke5, Nima Sharifai6, Kristen Stashek7, Ignacio Ruz-Caracuel8, Daniela Allende9, Kelsey McHugh10, Jinru Shia11, Teri A Longacre12, Deepti Dhall13, Elias Makhoul13, Michael J Lee14, Katrina Collins15, Thomas M Ulbright15, M Lisa Zhang16, Maria Westerhoff17, Zu-Hua Gao18, Karen Matsukuma19, Won-Tak Choi20, Sanjay Kakar20, Runjan Chetty21, Klaudia Nowak22, Stefano Serra22, Xuchen Zhang23, Wei Chen24, Raul S Gonzalez25
1Department of Pathology, Lehigh Valley Health Network/Health Network Laboratories, Allentown.
2Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai.
3Department of Pathology, The Ohio State University, Columbus.
4Department of Pathology, University of Rochester Medical Center, Rochester, NY.
5Department of Pathology, Brigham and Women's Hospital.
6Department of Pathology, University of Maryland, Baltimore, MD.
7Department of Pathology, University of Pennsylvania, Philadelphia, PA.
8Department of Pathology, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERONC, Madrid, Spain.
9Department of Pathology, Cleveland Clinic, Cleveland, OH.
10Department of Pathology, Mayo Clinic Arizona, Scottsdale, AZ.
11Department of Pathology, Memorial Sloan Kettering Cancer Center, New York.
12Department of Pathology, Stanford University, Stanford.
13Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
14Department of Pathology, Columbia University.
15Department of Pathology, University of Indiana, Indianapolis, IA.
16Department of Pathology, Massachusetts General Hospital, Boston, MA.
17Department of Pathology, University of Michigan, Ann Arbor, MI.
18Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver.
19Department of Pathology, University of California Davis, Sacramento.
20Department of Pathology, University of California San Francisco, San Francisco, CA.
21Diagnexia, Dublin, Ireland.
22Department of Pathology, University of Toronto, Toronto, Canada.
23Department of Pathology, Yale University, New Haven, CT.
24Department of Pathology, Duke University, Durham, NC.
25Department of Pathology, Emory University School of Medicine, Atlanta, GA.
PubMed DOI

Abstract

Enteroblastic, hepatoid, and clear cell carcinomas are rare subtypes of colorectal carcinoma (CRC) with histologic and immunohistochemical (IHC) overlap. We assessed 37 CRCs that possibly represent these subtypes. Provisional criteria for each subtype, along with case photomicrographs and IHC data, were circulated among the authors to provide diagnostic interpretations. Based on plurality consensu…

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