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Peer-Reviewed Publication
Biol Psychiatry2026April 15, 2026Journal Article

Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers: A Disordinal Effect.

Marco Cecchi1, Jason Johannesen2, Brandon J Farley2, Michael C Quirk2, Mahdi Mahmoud-Zadeh3, Jason M Uslaner4, Ryan Terry-Lorenzo3, Daniel G Smith5, David A Ruhl3, Michael Rotte6, Austin L Reese3, Patricio O'Donnell7, Jennifer E Mollon8, Christopher Missling9, Yasuji Matsuoka10, Michael J Marino4, Susi Lee4, Igor O Korolev11, Daniel Klamer9, Anna Jeong10, Sokichi Honda12, K C Fadem11, Jim Doherty13, Elan A Cohen14, Soren Christensen15, Heramb Chadchankar16, Derek L Buhl10, Megumi Adachi12, Deepak C D'Souza17, Holly K Hamilton18, Mohini Ranganathan17, Brian J Roach19, Larry Ereshefsky20, David P Walling21, William Z Potter22, Daniel C Javitt23, Daniel H Mathalon24
1Cognision, Louisville, Kentucky. Electronic address: mcecchi@cognision.com.
2Sage Therapeutics, Cambridge, Massachusetts.
3Neurocrine Biosciences, San Diego, California.
4Merck & Co., Inc., Rahway, New Jersey.
5Alkermes, Waltham, Massachusetts.
6Novartis, Cambridge, Massachusetts.
7Alto Neuroscience, Mountain View, California.
8AbbVie Deutschland GmbH & Co. KG, Wiesbaden, Germany.
9Anavex Life Sciences Corporation, New York, New York.
10AbbVie, North Chicago, Illinois.
11Cognision, Louisville, Kentucky.
12Astellas Pharma, South San Francisco, California.
13Acumen Pharmaceuticals, Newton, Massachusetts.
14CenExel HRI, Marlton, New Jersey.
15Lundbeck, Copenhagen, Denmark.
16Kynexis, Cambridge, Massachusetts.
17Yale University and Veterans Affairs Connecticut Health Care System, West Haven, Connecticut.
18University of Minnesota and Veterans Affairs Minneapolis Health Care System, Minneapolis, Minnesota.
19Northern California Institute for Research and Education, San Francisco, California.
20Follow the Molecule LLC, Los Angeles, California; CenExel Research, Los Angeles, California; University of Texas Health Science Center at San Antonio, San Antonio, Texas.
21CenExel Research, Los Angeles, California.
22Independent Consultant, Philadelphia, Pennsylvania.
23Columbia University, New York, New York.
24University of California San Francisco and Veterans Affairs San Francisco Health Care System, San Francisco, California.
PubMed DOI

Abstract

BACKGROUND: Mismatch negativity (MMN) is a component of the auditory event-related potential (ERP) that is elicited during a passive oddball paradigm where task-irrelevant infrequent deviants are presented in a stream of more frequent standard stimuli. MMN is believed to index a preattentive stage of auditory information processing closely linked to NMDA receptor (NMDAR) function. Ketamine is thou…

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