Peer-Reviewed Publication
Ann Med2026;58(1):2654291.December 1, 2026Journal Article
Integrated radiopathomics nomogram for predicting angiogenic microvascular patterns in NSCLC: a dual-center validation study.
Ronghua Wang1, Lin Wang2, Xinzheng Wang3, Shuai Quan4, Linning E3,5, Jiangfeng Du6
1Department of Radiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
2Department of Pathology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.
3Department of Radiology, The People's Hospital of Longhua, Shenzhen, China.
4GE HealthCare, Shanghai, China.
5Department of Radiology, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan, China.
6Department of Medical Imaging, Shanxi Key Laboratory of Intelligent Imaging, First Hospital of Shanxi Medical University, Taiyuan, China.
Abstract
BACKGROUND: To develop and validate an integrated radiopathomics nomogram combining multiphase CT images, H&E-stained slides, and clinicopathological variables for predicting microvascular patterns (MVPs) in non-small cell lung cancer (NSCLC).
METHODS: We retrospectively included consecutive surgically resected NSCLC patients from two centers (n = 258). Patients from center 1 were randomly divide…
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