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Peer-Reviewed Publication
Clin J Am Soc Nephrol2026;21(6):972-983.June 1, 2026Journal Article

Adverse Muscle Composition Is Associated with All-Cause Mortality in CKD: A UK Biobank Imaging Study.

Ainhoa Indurain1,2, Markus Karlsson3, Anders Fernström1,2, Fredrik Uhlin1,2,4, Mårten Segelmark5,6, Olof Dahlqvist Leinhard2,3,7
1Departments of Nephrology, Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
2Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
3AMRA Medical AB, Linköping, Sweden.
4Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.
5Department of Clinical Sciences, Lund University, Lund, Sweden.
6Department of Endocrinology, Nephrology and Rheumatology, Skane University Hospital, Lund, Sweden.
7Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
PubMed PMC DOI PDF

Abstract

KEY POINTS: Adverse muscle composition is common in CKD; affected individuals face a higher risk of premature death. Adverse muscle composition is an independent and strong predictor of all-cause mortality in CKD. Muscle health evaluation can identify patients at high risk and support targeted prevention strategies. BACKGROUND: Adverse muscle composition (AMC), defined by low muscle volume and in…

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