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Peer-Reviewed Publication
J Clin Transl Endocrinol2026;44100437.May 1, 2026Journal Article

A functional medicine approach to diabetes control and quality of life: an open-label randomized pilot study.

Mohamed Eldib1, Betul Hatipoglu2, Michelle Beidelschies3, Marilyn Alejandro-Rodriguez4, Huijun Xiao5, Michael Rothberg6, Mark Hyman7, Keren Zhou1
1Department of Diabetes, Endocrinology and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
2Department of Medicine, Case Western Reserve University School of Medicine, Diabetes and Obesity Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
3Center for Functional Medicine, Cleveland Clinic, OH, USA.
4Department of Community Health, Mercy Health, Lorain, OH, USA.
5Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
6Center for Value-Based Care Research, Cleveland Clinic, Cleveland, OH, USA.
7Function Health, Lenox, MA, USA.

Abstract

BACKGROUND: There has been increasing public interest in a functional medicine (FM) approach to the care of type 2 diabetes (T2D). However, it is unclear if this approach can further improve diabetes management beyond conventional diabetes care. This study compared the addition of a FM approach (intensive lifestyle modifications and tailored dietary supplements) plus usual care (FM) to conventiona…

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