Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status.

Jieun Lee^1,2, Ju Yeon Kwak^1,3,4, Ho Yeop Lee^1,3, Ji Sun Moon¹, Hyo Ju Jang^1,3, Ha Thi Nga^1,3, Thi Linh Nguyen^1,3, Alfin Mohammad Abdillah^1,3, Junglyun Kim², Sihwan Kim^5,6, Yong Ryoul Yang⁴, Jeong Eun Lee⁷, Hyon-Seung Yi^8,9

¹Laboratory of Endocrinology and Immune System, Chungnam National University College of Medicine, Daejeon, Korea.

²Chungnam National University College of Nursing, Daejeon, Korea.

³Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Korea.

⁴Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

⁵Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.

⁶ClariPi Research, ClariPi, Seoul, Korea.

⁷Department of Radiology, Chungnam National University Hospital, Daejeon, Korea. nasa80@cnuh.co.kr.

⁸Laboratory of Endocrinology and Immune System, Chungnam National University College of Medicine, Daejeon, Korea. jmpbooks@cnu.ac.kr.

⁹Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Korea. jmpbooks@cnu.ac.kr.

PubMed PMC DOI PDF

Abstract

BACKGRUOUND: Catecholamines play a crucial role in muscle biogenesis, but their persistent elevation is linked to muscle wasting, which is poorly understood. This study aimed to investigate the association between catecholamine levels and age-related muscle loss. METHODS: This retrospective study evaluated the plasma levels of two catecholamines, metanephrine and normetanephrine, and the clinical…

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Mentioned Companies

ClariPI
affiliation

Other Funding

Korea Health Industry Development Institute
Ministry of Health and Welfare(RS-2024-00507183)
Ministry of Health and Welfare(RS-2022-KH130308)
National Research Foundation of Korea(2021R1A5A8029876)
National Research Foundation of Korea(2023R1A2C3006220)
Ministry of Science, ICT and Future Planning
National Research Council of Science and Technology(CRC22011-200)
Ministry of Science and ICT

MeSH Terms

Male0Humans0Female0Animals0Retrospective Studies0Extracellular Signal-Regulated MAP Kinases*Catecholamines*Aged0Receptors, Adrenergic, beta*Normetanephrine*Metanephrine*Middle Aged0Mice0Cross-Sectional Studies0Muscle Development0Muscle, Skeletal*Adrenal Gland Neoplasms0Muscular Atrophy*

Keywords

CatecholaminesMuscle developmentMusclesβ-Adrenergic signaling

Article Info

PMID: 41937554
PMCID: PMC13172642
DOI: 10.3803/EnM.2025.2527
Received: June 30, 2025
Accepted: December 11, 2025

How to Cite

Lee J et al. Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status. Endocrinol Metab (Seoul)2026;41(2):319-332. doi:10.3803/EnM.2025.2527

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