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Peer-Reviewed Publication
JACC Adv2026;5(4):102663.April 1, 2026Journal Article

AI-Enhanced Electrocardiogram for Detection of Occlusive Myocardial Infarction in High-Risk Non-ST-Segment Elevation Acute Coronary Syndrome.

Pedro E P Carvalho1, Will Belzer1, Daniel L Pollmann2, Hans C Helseth3, Jay H Traverse4, Robert Herman5, Deniz Mutlu1, Anil Poulose4, Michael Mooney4, M Nicholas Burke4, Konstantinos Voudris4, Mario Goessl4, Ivan Chavez4, Yale L Wang4, Dimitrios Strepkos1, Michaella Alexandrou1, Ellen Cravero6, Bavana V Rangan1, Allan S Jaffe7, Emmanouil S Brilakis8, Scott W Sharkey1, Yader Sandoval9
1Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.
2Department of Internal Medicine, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
3Emergency Department, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
4Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
5Cardiovascular Center Aalst, AZORG, Aalst, Belgium; Powerful Medical, Bratislava, Slovakia.
6Biostatistic Unit, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.
7Department of Cardiovascular Medicine and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA.
8Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA; Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
9Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA; Allina Health Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA. Electronic address: yadersandoval@gmail.com.

Abstract

BACKGROUND: Whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) improves detection of occlusive myocardial infarction (OMI) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) compared with standard of care (SOC) remains uncertain. OBJECTIVES: The objective of the study was to evaluate an AI-ECG model for detecting OMI among patients with suspected high-risk NSTE-ACS…

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