Peer-Reviewed Publication
Cell Rep2026;45(3):117048.March 24, 2026Journal Article
Similar destabilization of neural dynamics under different general anesthetics.
Adam J Eisen1, Alexandra G Bardon2, Jesus J Ballesteros3, André M Bastos4, Jacob A Donoghue5, Meredith K Mahnke6, Scott L Brincat2, Jefferson E Roy2, Yumiko Ishizawa7, Emery N Brown8, Ila R Fiete9, Earl K Miller10
1The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Department of Psychology, Ruhr-Universität-Bochum, 44801 Bochum, Germany.
4Department of Psychology, Vanderbilt University, Nashville, TN 37235, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37235, USA.
5Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Beacon Biosignals, Boston, MA 02114, USA.
6The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
7Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02139, USA.
8The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02139, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
9McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: fiete@mit.edu.
10The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: ekmiller@mit.edu.
Abstract
Different classes of anesthetics induce unconsciousness despite acting through distinct molecular mechanisms, raising the possibility that their convergent effects arise at the level of the dynamics of neural population activity. To explore this, we analyze intracortical electrophysiological recordings during infusions of propofol, ketamine, and dexmedetomidine, applying a rigorous method to estim…
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