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Peer-Reviewed Publication
Nat Commun2026;17(1)March 8, 2026Journal Article

Multimodal evidence for hippocampal engagement and modulation by functional connectivity-guided parietal TMS.

Zhuoran Li1,2,3, Nicholas T Trapp2,3,4, Joel Bruss1, Xianqing Liu1, Kang Wu1, Ziyan Chen1, Amit Etkin5, Matthew A Howard4,6, Aaron D Boes1,2,3,4, Jing Jiang7,8,9
1Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
2Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
3Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
4Department of Neurology, University of Iowa, Iowa City, IA, USA.
5Alto Neuroscience, Mountain View, CA, USA.
6Department of Neurosurgery, University of Iowa, Iowa City, IA, USA.
7Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA, USA. jing-jiang@uiowa.edu.
8Department of Psychiatry, University of Iowa, Iowa City, IA, USA. jing-jiang@uiowa.edu.
9Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA. jing-jiang@uiowa.edu.
PubMed PMC DOI PDF

Abstract

Hippocampal activity supports memory and many other brain functions. Transcranial magnetic stimulation (TMS) guided by hippocampal functional connectivity (FC) shows promise in improving memory, but direct neural evidence of its capacity to engage and modulate hippocampal activity is lacking. Here we combined TMS with intracranial electroencephalography (iEEG) in 8 neurosurgical patients and with…

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