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Peer-Reviewed Publication
Acta Pharmacol Sin2026;47(7):1917-1930.July 1, 2026Journal Article

Chloroethylnitrosourea analogue HJ03 overcomes temozolomide resistance of glioblastoma in mice through induction of ferroptosis and apoptosis.

Heng Yang1, Yi Cao1, Wei Zhao1, Ying-Fan Wen1, Yan Wu1, Ting Wang2, Li-Zhi Zhu3,4, Yong-Dong Zou5, Bao-Min Xi6, Duo Zheng7
1Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen Key Laboratory of Translational Medicine in Oncology, School of Basic Medical Sciences, School of Pharmaceutical Sciences, Medical School; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518035, China.
2Guangzhou KemRocMed Co., Ltd., Guangzhou, 510320, China.
3Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen Key Laboratory of Translational Medicine in Oncology, School of Basic Medical Sciences, School of Pharmaceutical Sciences, Medical School; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518035, China. lzzhu86@pku.edu.cn.
4Shenzhen Zhonghe Headway Bio-Sci & Tech Co., Ltd., Shenzhen, 518057, China. lzzhu86@pku.edu.cn.
5Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen Key Laboratory of Translational Medicine in Oncology, School of Basic Medical Sciences, School of Pharmaceutical Sciences, Medical School; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518035, China. zouyd@szu.edu.cn.
6Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. xibaomin@smu.edu.cn.
7Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen Key Laboratory of Translational Medicine in Oncology, School of Basic Medical Sciences, School of Pharmaceutical Sciences, Medical School; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518035, China. dzheng@szu.edu.cn.
PubMed PMC DOI PDF

Abstract

Surgery followed by adjuvant chemoradiation is the standard treatment for glioblastoma multiforme (GBM). Temozolomide (TMZ) is the only first-line chemotherapeutic drug approved by the US Food and Drug Administration for the treatment of GBM. Acquired chemoresistance to TMZ is the primary cause of treatment failure, resulting in recurrence and a poor prognosis. O6-methylguanine DNA methyltransfera…

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