Impact of a structured quantitative program on [18F]FP-CIT PET interpretation: a multicenter study of diagnostic accuracy, interrater reliability, and reader confidence.

Byungwook Choi¹, Seunggyun Ha², Sungmin Kang¹, Soo Jin Kwon^2,3, Junik Son⁴, Shin Young Jeong^4,5, Sang-Woo Lee^4,5, Yeong Sim Choe⁶, Donghyeon Kim⁶, Chae Moon Hong^4,5

¹Department of Nuclear Medicine, Daegu Catholic University Hospital and School of Medicine, Daegu, 42472, Republic of Korea.

²Division of Nuclear Medicine, Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06592, Republic of Korea.

³Division of Nuclear Medicine, Department of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 03312, Republic of Korea.

⁴Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea.

⁵Department of Nuclear Medicine, Kyungpook National University School of Medicine, Daegu, 41944, Republic of Korea.

⁶Research Institute, Neurophet Inc, Seoul, 06234, Republic of Korea.

PubMed DOI

Abstract

OBJECTIVES: This study assessed the impact of a structured quantitative analysis program on diagnostic performance, interrater reliability, and reader confidence in interpreting N-3-[18F]fluoropropyl-2β-carbomethoxy-3β-4-iodophenyl nortropane positron emission tomography ([18F]FP-CIT PET) scans to differentiate idiopathic Parkinson's disease from essential tremor-/drug-induced parkinsonism. METHO…

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Mentioned Companies

NEUROPHET
affiliation

Other Funding

Korea Health Industry Development Institute and Daegu Metropolitan city

MeSH Terms

Humans0Reproducibility of Results0Retrospective Studies0Positron-Emission Tomography*Sensitivity and Specificity0Observer Variation0Female0Parkinson Disease*Male0Tropanes*Aged0Radiopharmaceuticals0Diagnosis, Differential0Magnetic Resonance Imaging0Middle Aged0Essential Tremor*Parkinsonian Disorders*

Keywords

FP-CIT PETdiagnostic performanceidiopathic Parkinson’s diseaseinterrater reliabilityquantitative analysis programreader confidence

Article Info

PMID: 41746303
DOI: 10.1093/bjr/tqag045
Received: September 22, 2025
Accepted: February 20, 2026

How to Cite

Choi B et al. Impact of a structured quantitative program on [18F]FP-CIT PET interpretation: a multicenter study of diagnostic accuracy, interrater reliability, and reader confidence. Br J Radiol2026;99(1181):980-988. doi:10.1093/bjr/tqag045

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