Severity of MASH activity by iron-corrected MRI predicts insulin resistance and cardiometabolic risk in type 2 diabetes.

Andrea Ortiz Rocha¹, Srilaxmi Kalavalapalli¹, Eddison Godinez Leiva¹, Diana Barb¹, Fernando Bril², Stephen A Marangi¹, Helena B Thomaides-Brears³, Jens T Rosenberg⁴, Nathaly Cuervo-Pardo¹, Romina Lomonaco¹, Enrique Valdez Saenz¹, Anu Sharma¹, Kenneth Cusi¹

¹Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Florida at Gainesville, FL 32610, USA.

²Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.

³Perspectum, Gemini One, 5520 John Smith Drive, Oxford, OX4 2LL, UK.

⁴Advanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute, University of Florida at Gainesville, FL 32610, USA.

PubMed PMC DOI PDF

Abstract

CONTEXT: Multiparametric magnetic resonance iron-corrected T1 mapping (cT1) may help identification and risk-stratification of steatohepatitis (MASH). OBJECTIVE: In type 2 diabetes, metabolic dysfunction-associated steatotic liver disease frequently advances to steatohepatitis with significant fibrosis and increased risk of developing cirrhosis. cT1 allows MASH risk-stratification by measuring li…

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