Health AI Central
Peer-Reviewed Publication
JACC Adv2026;5(2):102572.February 1, 2026Journal Article

Artificial Intelligence-Enhanced Electrocardiogram Models for Detection of Left Ventricular Dysfunction: A Comparison Study.

Philip M Croon1, Machteld J Boonstra2, Cornelis P Allaart3, Bauke K O Arends4, Lovedeep S Dhingra5, Yu-Chang Huang6, Thomas Mast7, Rohan Khera8, Chang-Fu Kuo9, Joon-Myoung Kwon10, Hak Seung Lee10, Min Sung Lee10, Rutger R van de Leur4, Zhi-Yong Liu11, Evangelos K Oikonomou5, Jasper L Selder3, Michiel M Winter3, Folkert W Asselbergs12
1Department of Cardiology, Amsterdam Cardiovascular Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, USA.
2Department of Cardiology, Amsterdam Cardiovascular Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Department of Medical Informatics, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
3Department of Cardiology, Amsterdam Cardiovascular Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
4Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
5Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, USA.
6Division of Cardiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
7Department of Cardiology, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
8Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, USA; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA; Section of Health Informatics, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.
9School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
10Digital Healthcare Institute, Sejong Medical Research Institute, Bucheon, Republic of Korea; Medical AI Co., Ltd., Seoul, Republic of Korea.
11Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
12Department of Cardiology, Amsterdam Cardiovascular Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; Institute of Health Informatics, University College London, London, United Kingdom; The National Institute for Health Research UCL Hospitals Biomedical Research Centre, University College London, London, United Kingdom. Electronic address: f.w.asselbergs@amsterdamumc.nl.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Several artificial intelligence-enhanced electrocardiogram (AI-ECG) models have shown promise in detecting left ventricular systolic dysfunction (LVSD), but their head-to-head agreement and performance have not been independently compared within the same cohort. OBJECTIVES: This study aimed to compare the performance of published AI-ECG models for LVSD detection in a standardized exte…

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