Peer-Reviewed Publication
J Neuroinflammation2026;23(1):60.January 15, 2026Journal Article
Diffuse neuroinflammation and immature neuron loss in fetal Rhesus macaques after short-term intrauterine infection.
Pietro Presicce1, Danielle Beckman2, Giovanne B Diniz2, Monica Cappelletti1, Sean Ott2, Sivan Bercovici3, Shiv Kale3, Paul Babb3, Jyodi Mohole1, Lauren S Richardson4, Ananth K Kammala4, Ramkumar Menon4, Lisa A Miller5, Elizabeth E Crouch6, Alan H Jobe7, Senad Divanovic8, Claire A Chougnet8, Sing Sing Way9, John H Morrison2, Suhas G Kallapur10
1Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, Mattel Children's Hospital UCLA, 10833 Le Conte Avenue, Room B2-375 MDCC, Los Angeles, CA, 90095, USA.
2California National Primate Research Center, University of California Davis, Davis, CA, USA.
3Karius, Inc, Redwood City, CA, USA.
4Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
5Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
6Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
7Division of Neonatology/Pulmonary Biology, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
8Division of Immunobiology, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
9Division of Infectious Diseases, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
10Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, Mattel Children's Hospital UCLA, 10833 Le Conte Avenue, Room B2-375 MDCC, Los Angeles, CA, 90095, USA. skallapur@mednet.ucla.edu.
Abstract
Chorioamnionitis or infection of the amniotic fluid and membranes surrounding the fetus can cause fetal systemic inflammation and adverse neurological outcomes. To investigate the pathogenesis of chorioamnionitis-induced neurological injury, we developed a non-human primate model by infusion of live Escherichia coli. A micro-osmotic pump was placed in pregnant Rhesus macaques at ~ 85% term gestati…
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