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Peer-Reviewed Publication
Biomech Model Mechanobiol2026;25(1):15.January 13, 2026Journal Article

Electromechanical computational modeling of heart failure provides extensive analysis of cardiac pathophysiological features.

Eva Casoni1, Alberto Zingaro2, Maite Mora3, Juan F Gómez4, Jose M Pozo2, Pablo González-Martín2, Mariano Vázquez2,5, Beatriz Trenor3, Jazmin Aguado-Sierra2
1ELEM Biotech S.L., Pier 07 - Via Laietana, 26, 08003, Barcelona, Spain. ecasoni@elem.bio.
2ELEM Biotech S.L., Pier 07 - Via Laietana, 26, 08003, Barcelona, Spain.
3Centro de Investigación e Innovación en Bioingeniería, Universitat Politècnica de València, Ciudad Politécnica de la Innovación, Camino de Vera s/n, 46022, Valencia, Spain.
4Valencian International University, C. del Pintor Sorolla, 21, Ciutat Vella, 46002, València, Spain.
5Barcelona Supercomputing Center, Plaça Eusebi Guell 1-3, 08034, Barcelona, Spain.
PubMed DOI

Abstract

This study applies a high-performance, fully coupled 3D-0D electromechanical model to simulate cardiac function across multiple scenarios of heart failure with reduced ejection fraction (HFrEF), including ventricular tachycardia post-myocardial infarction and acute hypertension. By integrating biomechanical deformation, electromechanical coupling, and hemodynamic feedback, the model provides a com…

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