Peer-Reviewed Publication
NPJ Parkinsons Dis2026;12(1):26.January 10, 2026Journal Article
Subthalamic nucleus in patients with Parkinson's disease encodes changes and magnitude of applied force.
Joseph Olson1, Shaikh Sharar Wahid1, Zachary T Irwin2, Daniel Kuhman3, Christopher L Gonzalez1, Maria Boolos4, Sarah Black1, Barton L Guthrie2, Thomas Wichmann5, Harrison C Walker6,7
1Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
2Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
3Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
4Brainlab, Inc., Westchester, IL, USA.
5Department of Neurology and National Primate Research Center, Emory University, Atlanta, GA, USA.
6Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. hcwalker@uabmc.edu.
7Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA. hcwalker@uabmc.edu.
Abstract
The subthalamic nucleus (STN), a primary target for Parkinson's disease (PD) neuromodulation therapies, contributes to movement dynamics but it is unknown how STN relates to specific kinematic parameters. We investigated the neuronal activity in the dorsolateral STN during a visually cued isometric grip-force task in the contralateral hand in patients with PD who were undergoing deep brain stimula…
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