Peer-Reviewed Publication
Br J Pharmacol2025;182 Suppl 1(Suppl 1):S24-S151.December 1, 2025Journal Article
The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.
Stephen P H Alexander1, Anthony P Davenport2, Eamonn Kelly3, Alasdair J Gibb4, Alistair A Mathie5, Chloe J Peach6, Emma L Veale7, Jane F Armstrong8, Elena Faccenda8, Simon D Harding8, Christopher Southan8, Jamie A Davies8, Maria Pia Abbracchio9, George R Abraham10, Alexander Agoulnik11, Wayne Alexander12, Khaled Al-Hosaini13, Magnus Bäck14, Jillian G Baker15, Nicholas M Barnes16, Ross Bathgate17, Jean-Martin Beaulieu18, Annette G Beck-Sickinger19, Maik Behrens20, Kirstie A Bennett21, Kenneth E Bernstein22, Bernhard Bettler23, Nigel J M Birdsall24, Victoria A Blaho25, Pascal Bonaventure26, Francois Boulay27, Corinne Bousquet28, Hans Bräuner-Osborne29, Andrew J Brown30, Geoffrey Burnstock31, Marta Busnelli32, Girolamo Caló33, Vanni Caruso34, Justo P Castaño35, Kevin J Catt36, Stefania Ceruti9, Paul Chazot37, Nan Chiang38, Bice Chini32, Arthur Christopoulos39, Jerold Chun40, Antonia Cianciulli41, Olivier Civelli42, Lucie H Clapp31, Réjean Couture43, Helen M Cox44, Zsolt Csaba45, Claes Dahlgren46, Frank M Dautzenberg47, Gordon Dent48, Steven D Douglas49, Pascal Dournaud45, Margarita L Dubocovich50, Satoru Eguchi51, Emanuel Escher52, Edward J Filardo53, Tung Fong54, Huamei Fu Forsman46, Marta Fumagalli9, Raul R Gainetdinov55, Michael L Garelja56, Marc de Gasparo57, Florence Gbahou45, Craig Gerard38, Marvin Gershengorn36, Michelle Glass56, David E Gloriam29, Fernand Gobeil52, Theodore L Goodfriend58, Cyril Goudet59, Lukas Grätz60, Karen J Gregory39, Christian Gruber61, Andrew L Gundlach17, Jörg Hamann62, Julien Hanson63, Deborah S Hartman64, Richard L Hauger40, Debbie L Hay56, Akos Heinemann65, Laura Heitman66, Deron R Herr67, Morley D Hollenberg68, Nicholas D Holliday15, Birgitte Holst29, Mastgugu Horiuchi69, Daniel Hoyer70, László Hunyady71, Ahsan Husain12, Adriaan P IJzerman66, Tadashi Inagami72, Paul A Insel40, Kenneth A Jacobson36, Laura H Jacobson17, Robert T Jensen36, Ralf Jockers45, Deepa Jonnalagadda25, Sadashiva Karnik73, Klemens Kaupmann74, Jacqueline Kemp75, Charles Kennedy76, Yasuyuki Kihara25, Julia Kinsolving60, Takio Kitazawa77, Pawel Kozielewicz60, Hans-Jürgen Kreienkamp78, Jyrki P Kukkonen79, Luxmichan Laishram75, Tobias Langenhan19, Christopher J Langmead39, Dan Larhammar80, Katie Leach39, Davide Lecca9, John D Lee81, Susan E Leeman82, Jérôme Leprince83, Rob Leurs84, Xaria X Li85, Ines Liebscher19, Stephen J Lolait86, Amelie Lupp87, Robyn Macrae10, Janet J Maguire10, Davide Malfacini33, Maurice Manning88, Davide Marangon9, Kirill Martemyanov89, Jean Mazella90, Craig A McArdle86, Shlomo Melmed22, Martin C Michel91, Laurence J Miller92, Vincenzo Mitolo41, Bernard Mouillac59, Christa E Müller93, Philip M Murphy36, Jean-Louis Nahon90, Richard R Neubig94, Tony Ngo25, Xavier Norel45, Duuamene Nyimanu10, Anne-Marie O'Carroll86, Stefan Offermanns95, Maria Antonietta Panaro41, Marc Parmentier96, Nicole Perry-Hauser97, Roger G Pertwee98, Jean-Philippe Pin99, Eric R Prossnitz100, Helena Chengxue Qin101, Mark Quinn102, Stefano Raffaele9, Rithwik Ramachandran68, Manisha Ray25, Rainer K Reinscheid87, Alejandro Romeral Buzón29, Philippe Rondard99, Mette M Rosenkilde29, G Enrico Rovati9, Chiara Ruzza103, Gareth J Sanger104, Nicole Scholz19, Torsten Schöneberg19, Gunnar Schulte60, Stefan Schulz87, Deborah L Segaloff105, Charles N Serhan38, Arun K Shukla106, Khuraijam Dhanachandra Singh75, Craig M Smith107, Nicola J Smith108, Claudia Stäubert19, Leigh A Stoddart109, Yukihiko Sugimoto110, Roger Summers101, Valerie P Tan40, David M Thal101, Walter Wally Thomas85, Pieter B M W M Timmermans111, Kalyan Tirupula75, Lawrence Toll112, Giovanni Tulipano113, Hamiyet Unal75, Thomas Unger114, Celine Valant101, Patrick Vanderheyden96, David Vaudry83, Hubert Vaudry83, Joseph G Verbalis115, Jean-Pierre Vilardaga116, Christopher S Walker117, Ji Ming Wang36, Donald T Ward118, Hans-Jürgen Wester20, Gary B Willars119, Tom Lloyd Williams10, Trent M Woodruff85, Huixian Wu120, Cheng Yang34, Chengcan Yao121, Richard D Ye122, Nathan Zaidman100
1Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
2Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
3School of Psychology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
4Research Department of Neuroscience, Physiology and Pharmacology, Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, UK.
5School of Life Sciences, University of Westminster, London, W1W 6UW, UK.
6Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, Centre of Membrane Proteins and Receptors (COMPARE), University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
7Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, Kent, ME4 4TB, UK.
8Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, EH8 9XD, UK.
9University of Milan, Milan, Italy.
10University of Cambridge, Cambridge, UK.
11Florida International University, Miami, USA.
12Emory University, Atlanta, USA.
13King Saud University, Riyadh, Kingdom of Saudi Arabia.
14Karolinska University Hospital, Stockholm, Sweden.
15University of Nottingham, Nottingham, UK.
16University of Birmingham, Birmingham, UK.
17Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
18University of Toronto, Toronto, Canada.
19Leipzig University, Leipzig, Germany.
20Technical University of Munich, Freising, Germany.
21Nxera Pharma UK Ltd, Cambridge, UK.
22Cedars-Sinai Medical Center, Los Angeles, USA.
23University of Basel, Basel, Switzerland.
24The Francis Crick Institute, London, UK.
25Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA.
26Janssen Research & Development, San Diego, USA.
27University of Grenoble Alpes, Grenoble, France.
28French Institute of Health and Medical Research (INSERM), Toulouse, France.
29University of Copenhagen, Copenhagen, Denmark.
30Ikherma Consulting Ltd, Hitchin, UK.
31University College London, London, UK.
32University of Milan Bicocca, Vedano al Lambro, Italy.
33University of Padova, Padova, Italy.
34University of Tasmania School of Medicine, Hobart, Australia.
35University of Córdoba, Córdoba, Spain.
36National Institutes of Health, Bethesda, USA.
37Durham University, Durham, UK.
38Harvard University, Boston, USA.
39Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Parkville, Australia.
40University of California San Diego, La Jolla, USA.
41University of Bari, Bari, Italy.
42University of California Irvine, Irvine, USA.
43University of Montréal, Montréal, Canada.
44King's College London, London, UK.
45French Institute of Health and Medical Research (INSERM), Paris, France.
46University of Gothenburg, Gothenburg, Sweden.
47Novaliq GmbH, Konstanz, Germany.
48Keele University, Newcastle-under-Lyme, UK.
49University of Pennsylvania, Pennsylvania, USA.
50University at Buffalo, Buffalo, USA.
51Temple University, Philadelphia, USA.
52University of Sherbrooke, Sherbrooke, Canada.
53Rhode Island Hospital, Providence, USA.
54Labcorp Drug Development, Somerset, USA.
55Saint Petersburg State University, Saint Petersburg, Russia.
56University of Otago, Dunedin, New Zealand.
57MG Consulting Co, Basel, Switzerland.
58University of Wisconsin, Madison, USA.
59French National Centre for Scientific Research, Montpellier, France.
60Karolinska Institute, Stockholm, Sweden.
61Medical University of Vienna, Vienna, Austria.
62Amsterdam University, Amsterdam, The Netherlands.
63University of Liège, Liège, Belgium.
64Takeda Development Center Americas, Inc., Boston, USA.
65Medical University of Graz, Graz, Austria.
66Leiden University, Leiden, The Netherlands.
67Indiana State University Foundation, Terre Haute, USA.
68University of Calgary, Calgary, Canada.
69Ehime University, Ehime, Japan.
70University of Melbourne, Melbourne, Australia.
71Semmelweis University, Budapest, Hungary.
72Vanderbilt University, Nashville, USA.
73Lerner Research Institute, Cleveland, USA.
74Novartis, Basel, Switzerland.
75Cleveland Clinic Lerner Research Institute, Cleveland, USA.
76Strathclyde University, Glasgow, UK.
77Rakuno Gakuen University, Ebetsu, Japan.
78University of Hamburg, Hamburg, Germany.
79University of Helsinki, Helsinki, Finland.
80Uppsala University, Uppsala, Sweden.
81University of Queensland, Brisbane, Australia.
82Boston University, Boston, USA.
83University of Rouen, Rouen, France.
84Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
85University of Queensland, Queensland, Australia.
86University of Bristol, Bristol, UK.
87Friedrich Schiller University Jena, Jena, Germany.
88University of Toledo College of Medicine, Toledo, USA.
89Scripps Research Institute, Jupiter, USA.
90French National Centre for Scientific Research (CNRS), Valbonne, France.
91Johannes Gutenberg University, Mainz, Germany.
92Mayo Foundation for Medical Education and Research, Scottsdale, USA.
93University of Bonn, Bonn, Germany.
94Michigan State University, East Lansing, USA.
95Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
96Free University of Brussels, Brussels, Belgium.
97University of Glasgow, Glasgow, UK.
98University of Aberdeen, Aberdeen, UK.
99University of Montpellier, Montpellier, France.
100University of New Mexico, Albuquerque, USA.
101Monash University, Melbourne, Australia.
102Montana State University, Bozeman, USA.
103University of Ferrara, Ferrara, Italy.
104Queen Mary University of London, London, UK.
105University of Iowa, Iowa City, USA.
106Indian Institute of Technology, Kanpur, India.
107Deakin University, Waurn Ponds, Australia.
108University of New South Wales, Sydney, Australia.
109Excellerate Bioscience, Nottingham, UK.
110Kumamoto University, Kumamoto, Japan.
111Kosan Biosciences Inc., San Francisco, USA.
112Florida Atlantic University, Jupiter, USA.
113University of Brescia, Brescia, Italy.
114Maastricht University, Maastricht, The Netherlands.
115Georgetown University Medical Center, Washington, DC, USA.
116University of Pittsburgh, Pittsburgh, USA.
117University of Auckland, Auckland, New Zealand.
118University of Manchester, Manchester, UK.
119University of Leicester, Leicester, UK.
120Pfizer Research & Development, Groton, USA.
121University of Edinburgh, Edinburgh, UK.
122The Chinese University of Hong Kong, Shenzhen, China.
Abstract
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than…
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