Higher Life-Course Blood Pressure Associates With Reduced Myocardial Perfusion in Older Age: Insights From MyoFit46.

Constantin-Cristian Topriceanu^1,2,3,4, Matthew Webber^1,2, Hunain Shiwani^1,2,5, Fiona Chan^1,2, Emma Martin^1,2, Debbie Falconer^1,2, Matthew A Stanley^1,2, Jonathan Bennett^1,2, Pablo Gonzalez-Martin^2,6, Haytham Shah^1,2, Swapnanil De^1,2, Andrew Wong^1,2, Iain Pierce⁵, Rhodri H Davies^1,2, Pier D Lambiase^2,5, Nishi Chaturvedi^1,2, Peter Kellman⁷, Rebecca Hardy⁸, James C Moon^2,5, Alun D Hughes^1,2, Gabriella Captur^1,2,3

¹Unit for Lifelong Health and Ageing at UCL (C.-C.T., M.W., H. Shiwani, F.C., E.M., D.F., M.A.S., J.B., H. Shah, S.D., A.W., R.H.D., N.C., A.D.H., G.C.), University College London, United Kingdom.

²UCL Institute of Cardiovascular Science (C.-C.T., M.W., H. Shiwani, F.C., E.M., D.F., M.A.S., J.B., P.G.-M., H. Shah, S.D., A.W., R.H.D., P.D.L., N.C., J.C.M., A.D.H., G.C.), University College London, United Kingdom.

³Cardiology Department, The Royal Free Hospital, Centre for Inherited Heart Muscle Conditions, London, United Kingdom (C.-C.T., G.C.).

⁴Mayo Clinic, Rochester, MN (C.-C.T.).

⁵Cardiac MRI Unit, Barts Heart Centre, London, United Kingdom (H. Shiwani, I.P., P.D.L., J.C.M.).

⁶ELEM Biotech SL, Barcelona, Spain (P.G.-M.).

⁷National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD (P.K.).

⁸School of Sport, Exercise and Health Sciences, Loughborough University, United Kingdom (R.H.).

PubMed PMC DOI PDF

Abstract

BACKGROUND: Elevated blood pressure (BP) is a major contributor to coronary artery disease. We explored the impact of life-course BP on later-life normalized stress myocardial blood flow (sMBFN) and myocardial perfusion reserve by cardiovascular magnetic resonance (CMR). METHODS: MyoFit46 prospectively recruited ≈500 National Survey of Health and Development 1946 birth cohort participants, aged ≈…

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