Gender Differences in Trajectories of Depressive Symptoms Among Talkspace Clients: Naturalistic Observational Study.

Meghan Romanelli¹, Julien Rouvere², Isaac A Sanders³, Aarthi Padmanabhan⁴, Emily Peake⁴, Thomas D Hull⁴, Tim Althoff⁵

¹School of Social Work, University of Washington, 4101 15th Avenue NE, Seattle, WA, 98105, United States, 1 206-685-6948.

²Department of Psychiatry and Behavioral Medicine, University of Washington School of Medicine, Seattle, WA, United States.

³School of Social Work University of Washington, Seattle, WA, United States.

⁴Talkspace, New York, NY, United States.

⁵Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, United States.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Gender minority populations experience an increased risk of depression and report significant barriers to accessing mental health services. While digital mental health (DMH) technologies may address barriers, it remains unclear how gender minority clients engage with DMH services and if DMH improves their clinical outcomes. OBJECTIVE: This naturalistic study explored gender difference…

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Mentioned Companies

Talkspace
affiliation

NIH Funding

Grant #11374851
Optimizing Engagement in Digital Mental Health Services among Sexual and Gender Minority Consumers
UNIVERSITY OF WASHINGTON
$127,742 (FY2026)

Other Funding

NIMH NIH HHS(K01 MH131795)
United States
NIMH NIH HHS(R01 MH125179)
United States

MeSH Terms

Humans0Female0Male0Adult0Depression*Middle Aged0Sex Factors0Telemedicine0Sexual and Gender Minorities*Mental Health Services0Psychotherapy*

Keywords

anxietydepressiondigital mental health interventionsgender identitytelemedicine

Article Info

PMID: 41340395
PMCID: PMC12675994
DOI: 10.2196/75290
Received: April 3, 2025
Accepted: October 28, 2025

How to Cite

Romanelli M et al. Gender Differences in Trajectories of Depressive Symptoms Among Talkspace Clients: Naturalistic Observational Study. JMIR Form Res2025;9e75290. doi:10.2196/75290

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