AI-driven spatial mapping of myxoid stroma and tumor-infiltrating lymphocytes in esophageal squamous cell carcinoma.

Keita Kouzu¹, Hironori Tsujimoto², Ines P Nearchou³, Takahiro Einama¹, Yoshiki Kajiwara¹, Takanori Watanabe⁴, Makiko Koga^1,4, Tomohiro Tsuru¹, Hiroyuki Horiguchi¹, Yoshihisa Yaguchi¹, Yoji Kishi¹, Hitoshi Tsuda⁵, Hideki Ueno¹

¹Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042, Japan.

²Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-0042, Japan. tsujihi@ndmc.ac.jp.

³Indica Labs, LCC., 8700 Education Pl NW, Bldg. B, Albuquerque, NM, 87114, USA.

⁴Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan.

⁵Pathology Center and Department of Pathology, Chiba Medical Center, 1-7-1 Minami-cho, Chuo-ku, Chiba, 260-0842, Japan.

PubMed DOI

Abstract

BACKGROUND: Myxoid stroma in the tumor stroma has been suggested to play a key role in cancer progression; however, its underlying mechanisms remain unclear. This study aimed to examine the relationship between myxoid stroma, identified in hematoxylin and eosin (HE)-stained tissue, and tumor-infiltrating lymphocytes (TILs), assessed through immunohistochemical staining. Automated image analysis wa…

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