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Peer-Reviewed Publication
Europace2025;27(11)October 31, 2025Journal Article

Women with persistent atrial fibrillation need more than pulmonary vein isolation: personalised extra-pulmonary vein ablation strategy vs. pulmonary vein isolation alone in the TAILORED-AF trial.

Isabel Deisenhofer1, Julien Seitz2, Marie-Sophie Nguyen-Tu3, Sabine Lotteau3, Clément Bars2, Jean-Paul Albenque4, Sonia Busch5, Edouard Gitenay2, Stavros Mountantonakis6, Antoine Roux7, Jérôme Horvilleur8, Babe Bakouboula9, Saumil Oza10, Selim Abbey11, Guillaume Theodore12, Antoine Lepillier13, Yves Guyomar14, Francis Bessière15, Jaap Jan Smit16, Anil Rajendra17, Daniel H Cooper18, Haroon Rashid19, Tom De Potter20, Christian De Chillou21, Seth Goldbarg22, Atul Verma23, Gustavo Morales17, Paola Milpied3, John D Hummel24, Jérôme Kalifa25
1Department of Electrophysiology, Technical University of Munich (TUM), German Heart Centre Munich, Lazarettstr. 36, 80636 Munich, Germany.
2Hôpital Saint Joseph, Marseille, France.
3Volta Medical, Marseille, France.
4Department of Cardiology-Heart Rhythm Management, Clinique Pasteur, Toulouse, France.
5Department of Electrophysiology, Herz-Zentrum Bodensee, Konstanz, Germany.
6Northwell Cardiovascular Institute, New Hyde Park, NY, USA.
7Pôle Santé République, Clermont-Ferrand, France.
8Hôpital Privé Jacques Cartier-Ramsay Santé-Institut Cardiovasculaire Paris Sud, Massy, France.
9Rhena, Strasbourg, France.
10Ascension St. Vincent's Riverside Hospital, Jacksonville, FL, USA.
11Hôpital Privé Le Confluent, Nantes, France.
12Clinique Saint George, Nice, France.
13Centre Cardiologique du Nord, Saint-Denis, France.
14Hôpital Saint Philibert, Lomme, France.
15Hopital Cardiologique Louis Pradel, Institut Cardiologique de Lyon, Hospices Civils de Lyon, Lyon, France.
16Isala Klinieken, Zwolle, The Netherlands.
17Grandview Medical Center, Arrythmia institute, Birmingham, AL, USA.
18Washington University, St. Louis, MO, USA.
19Inova, Fairfax, VA, USA.
20Cardiovascular Center, AZORG, Aalst, Belgium.
21Département de Cardiologie, CHU de Nancy, Nancy, France.
22New York Presbyterian Queens Division of Cardiology, Flushing, NYC, USA.
23McGill University Health Centre, Montreal, QC, Canada.
24The Ohio State University Wexner Medical Center, Columbus, OH, USA.
25Volta Medical, Inc., Providence, RI, USA.
PubMed PMC DOI PDF

Abstract

AIMS: There is still conflicting evidence if women with persistent atrial fibrillation (AF) profit from a pulmonary vein isolation (PVI) plus strategy. We evaluated the efficacy of a spatio-temporal dispersion-targeted ablation strategy in women from the TAILORED-AF trial. METHODS AND RESULTS: In TAILORED-AF, 370 patients were randomised to either a personalised, artificial intelligence (AI)-guid…

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