A rapid and dynamic role for FMRP in the plasticity of adult neurons.

Daniel G Gundermann^1,2, Seana Lymer^1,3, Jennifer Lennon¹, Justin Blau^4,5

¹Department of Biology, New York University, New York, NY, USA.

²Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA.

³Element Biosciences, San Diego, CA, USA.

⁴Department of Biology, New York University, New York, NY, USA. justin.blau@nyu.edu.

⁵Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE. justin.blau@nyu.edu.

PubMed PMC DOI PDF

Abstract

Fragile X syndrome is a neurodevelopmental disorder caused by silencing Fragile X messenger ribonucleoprotein 1 (Fmr1), which encodes the FMRP RNA-binding protein. Although Fmr1 is expressed in adult neurons, it has been challenging to separate acute from chronic effects of loss of Fmr1. Here we use the precision of Drosophila genetics to show that FMRP acutely regulates neuronal plasticity in adu…

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Mentioned Companies

Element Biosciences
affiliation

Other Funding

NCRR NIH HHS(C06 RR015518)
United States
NIGMS NIH HHS(R01 GM084947)
United States
NIGMS NIH HHS(R35 GM136363)
United States
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)(2R35GM136363)

MeSH Terms

Fragile X Messenger Ribonucleoprotein 1*Animals0Neuronal Plasticity*Drosophila Proteins*Neurons*Drosophila melanogaster0rac1 GTP-Binding Protein0Circadian Rhythm0Circadian Clocks0Male0Animals, Genetically Modified0

Article Info

PMID: 41276503
PMCID: PMC12749007
DOI: 10.1038/s41467-025-66487-0
Received: August 17, 2023
Accepted: November 10, 2025

How to Cite

Gundermann DG et al. A rapid and dynamic role for FMRP in the plasticity of adult neurons. Nat Commun2025;16(1):11578. doi:10.1038/s41467-025-66487-0

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