Peer-Reviewed Publication
Diagn Pathol2025;20(1):135.November 21, 2025Journal Article
Prognostic value of manual and digital PD-L1 expression in pT3 and pT4 colon cancer.
Dea Natalie Munch Jepsen1,2, Marianne Bøgevang Jensen1, Astrid Louise Bjørn Bennedsen2, Trine Lønbo Grantzau3, Thomas Thiilmark Eriksen4, Jens Ole Eriksen1, Michael Bzorek1, Ismail Gögenur2,5, Anne-Marie Kanstrup Fiehn6,7
1Department of Pathology, Zealand University Hospital, Roskilde, Denmark.
2Center for Surgical Science, Department of Surgery, Zealand University Hospital, Køge, Denmark.
3Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
4Visiopharm A/S, Hoersholm, Denmark.
5Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
6Department of Pathology, Zealand University Hospital, Roskilde, Denmark. ankf@regionsjaelland.dk.
7Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. ankf@regionsjaelland.dk.
Abstract
BACKGROUND: Programmed death ligand 1 (PD-L1) is a prognostic marker in several malignancies, but the prognostic value of PD-L1 expression in colorectal cancer (CRC) is inconclusive. Lack of standardized scoring systems for PD-L1 evaluation in CRC has led to inconsistent findings. This exploratory study aimed to evaluate PD-L1 expression using manual and digital methods and correlate the results t…
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