Evaluating effectiveness and engagement strategies for asynchronous, messaging, trauma-focused therapy for posttraumatic stress disorder: Study design and methodology for a hybrid effectiveness-implementation randomized controlled trial.

Katherine A Dondanville¹, Amber Calloway², Elizabeth C Stade³, Thomas D Hull⁴, Booil Jo⁵, Szu-Chi Huang⁵, Brittany N Hall-Clark⁶, Stefanie T LoSavio⁶, Bailee Schuhmann⁶, Sohayla Elhusseini⁷, Nicole Fridling-Cook⁴, Cyrus Pattee⁶, Aarthi Padmanabhan⁴, Shannon Wiltsey Stirman⁷

¹Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at San Antonio, United States of America. Electronic address: Dondanville@uthscsa.edu.

²Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States of America.

³Institute of Human-Centered Artificial Intelligence, Stanford University, Palo Alto, CA, United States of America; Department of Psychology, Stanford University, Palo Alto, CA, United States of America.

⁴Talkspace, New York, NY, United States of America.

⁵Institute of Human-Centered Artificial Intelligence, Stanford University, Palo Alto, CA, United States of America.

⁶Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at San Antonio, United States of America.

⁷National Center for PTSD, VA Palo Alto Healthcare System, United States of America; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, United States of America.

PubMed PMC DOI PDF

Abstract

Posttraumatic stress disorder (PTSD) can be a chronic and debilitating condition with significant individual and societal costs. Despite the availability of effective, trauma-focused treatments like Cognitive Processing Therapy (CPT), access and sustained engagement remain limited due to logistical, financial, and stigma-related barriers. The current study utilized a hybrid effectiveness-implement…

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Mentioned Companies

Talkspace
affiliation

NIH Funding

Grant #10362027
Telehealth 2.0: Evaluating effectiveness and engagement strategies for asynchronous texting based trauma focused therapy for PTSD
STANFORD UNIVERSITY
$2,792,355 (FY2021)

Other Funding

NIMH NIH HHS(RF1 MH128785)
United States

MeSH Terms

Humans0Stress Disorders, Post-Traumatic*Cognitive Behavioral Therapy*Text Messaging*Adult0Female0Male0Randomized Controlled Trials as Topic0Middle Aged0Motivation0

Keywords

Cognitive processing therapyDigital mental healthMessaging therapyPosttraumatic stress disorderTrauma

Article Info

PMID: 41270826
PMCID: PMC13356702
DOI: 10.1016/j.cct.2025.108149
Received: August 25, 2025
Accepted: November 16, 2025

How to Cite

Dondanville KA et al. Evaluating effectiveness and engagement strategies for asynchronous, messaging, trauma-focused therapy for posttraumatic stress disorder: Study design and methodology for a hybrid effectiveness-implementation randomized controlled trial. Contemp Clin Trials2026;160108149. doi:10.1016/j.cct.2025.108149

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