Spatial profiling of HPV-stratified head and neck squamous cell carcinoma reveals distinct immune niches and microenvironmental architectures.

Ettai Markovits¹, Dmytro Klymyshyn², Roni Froumine³, Hailing Zong², Michael Mints³, Sangeetha Mahadevan², Kenneth Bloom³, Jamie Bates², Gareth J Thomas⁴, Lauri Diehl², Oscar Puig³, Abhishek Aggarwal⁵

¹Nucleai, Tel Aviv, Israel. ettai.markovits@nucleai.ai.

²Gilead Sciences Inc., Foster City, CA, USA.

³Nucleai, Tel Aviv, Israel.

⁴University of Southampton, Southampton, UK.

⁵Gilead Sciences Inc., Foster City, CA, USA. abhishek.aggarwal5@gilead.com.

PubMed PMC DOI PDF

Abstract

BACKGROUND: HPV status is a key determinant of prognosis and treatment response in head and neck squamous cell carcinoma (HNSCC). To investigate how HPV influences the tumor-immune-stromal landscape, we performed high-dimensional spatial profiling, including its impact on spatial organization, tertiary lymphoid structures (TLSs), and spatially organized cellular neighborhoods. METHODS: Tumor biop…

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