Peer-Reviewed Publication
J Cereb Blood Flow Metab2026;46(3):773-785.March 1, 2026Journal Article
Estimating blood oxygen saturation through susceptibility source separation: A new standpoint on quantitative BOLD models.
Lucie Chalet1,2,3, Sébastien Rigollet4, Vasile Stupar4,5, Aurélien Delphin5, Thomas Coudert4, Benjamin Lemasson4, Emmanuel L Barbier4,5, Laura Mechtouff1,6, Timothé Boutelier3, Emmanuelle Canet-Soulas1, Thomas Christen4
1Cardiovascular Diseases, Metabolism, Diabetology and Nutrition Laboratory, INSERM U1060, Universite Claude Bernard Lyon 1, Lyon, France.
2Department of Neuroscience Imaging and Clinical Sciences (DNISC), Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio University" of Chieti-Pescara, Chieti, Italy.
3Olea Medical, La Ciotat, France.
4INSERM U1216, Grenoble Institut Neurosciences, University Grenoble Alpes, Grenoble, France.
5INSERM US17, CNRS, UAR3552, CHUGA, IRMaGe, University Grenoble Alpes, Grenoble, France.
6Stroke Department, Hospices Civils de Lyon, Lyon, France.
Abstract
MR methods have been proposed to estimate blood oxygen saturation in cerebral tissues by exploiting the magnetic susceptibility difference between oxy and deoxyhemoglobin. These models neglect the contribution of extravascular susceptibility sources leading to inaccurate measurements. Recent approaches combined quantitative BOLD and QSM methods, but these models neglected the impact of the geometr…
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