Health AI Central
Peer-Reviewed Publication
Clin J Am Soc Nephrol2026;21(1):46-60.January 1, 2026Journal Article

Joslin Kidney Panel of Circulating Proteins: A Tool for ESKD Risk Discrimination and Individualized Diabetic Kidney Disease Treatment.

Andrzej S Krolewski1,2, Jani K Haukka3,4,5, Zaipul I Md Dom1,2, Viktor R Curovic6, Chunyi Wu7, Mario Luca Morieri1,2, Katsuhito Ihara1,2,8, Sok Cin Tye1,2, Hiroki Kobayashi1,2,9, Youngshin Keum1,2, Sathishkumar Baskaran10, Stefan Mutter3,4,5, Simone Theilade6, Eiichiro Satake1,2, Narges Rashidi10, Valma Harjutsalo3,4,5, Tarunveer S Ahluwalia6,11, Monika A Niewczas1,2, Fergus Fleming12, Marlon Pragnell13, Robert G Nelson1, Joseph V Bonventre2,14, Per-Henrik Groop3,4,5,15,16, Peter Rossing6,11, Niina Sandholm3,4,5, Andrzej Galecki7,17, Alessandro Doria1,2
1Research Division, Joslin Diabetes Center, Boston, Massachusetts.
2Department of Medicine, Harvard Medical School, Boston, Massachusetts.
3Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
4Department of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
5Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
6Steno Diabetes Center Copenhagen, Herlev, Denmark.
7Institute of Gerontology, University of Michigan Medical School, Ann Arbor, Michigan.
8Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan.
9Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan.
10Olink Inc., Waltham, Massachusetts.
11University of Copenhagen, Copenhagen, Denmark.
12Renalytix, New York City, New York.
13JDRF International, New York City, New York.
14Renal Division, Brigham and Women's Hospital, Boston, Massachusetts.
15Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
16Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
17Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.
PubMed PMC DOI PDF

Abstract

KEY POINTS: A custom-made Joslin OLINK proteomics platform was developed to quantify 21 Joslin kidney panel (JKP) proteins in circulation to predict ESKD risk. Each JKP protein discriminated moderately/well ESKD risk in diabetes; optimal predictive model included three clinical markers and eight JKP proteins. In the type 2 diabetes subgroup from the Action to Control Cardiovascular Risk in Diabete…

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