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Peer-Reviewed Publication
Sci Rep2025;15(1):34931.October 7, 2025Journal Article

A novel thermochromic myocardial phantom for radiofrequency ablation and cryoablation.

Carlo Saija1,2, Sukruth Pradeep Kundur3, Lisa Leung3,4, Sachin Sabu3,5, Marco Pinto5,6, Mark Herridge5, Adharvan Gabbeta3, Rashi Chavan3, Nadia Chowdry3, Gregory Gibson5, Calum Byrne5, Antonia Pontiki3, Richard James Housden3, Pierre Berthet-Rayne7,8, Jonathan M Behar3,5, Kawal Rhode3
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. carlo.saija@kcl.ac.uk.
2Caranx Medical, Nice, France. carlo.saija@kcl.ac.uk.
3School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
4St. George's Hospital, London, UK.
5St Thomas Hospital, London, UK.
6Biosense Webster, Irvine, USA.
7Caranx Medical, Nice, France.
83IA Côte d'Azur, Université Côte D'Azur, Nice, France.

Abstract

In the growing field of electrophysiology, cardiac ablation either via heating or freezing target tissues using catheters, induces localised scarring to block or destroy defective electrical pathways in the heart. To test equipment and ablation settings, studies have resorted to ex-vivo and in-vivo models including pigs, dogs, and chickens. The use of animal tissue presents ethical and logistical…

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