Translating FLASH to the clinic: treatment planning system for a FLASH-compatible dose delivery using a novel x-ray UHDR machine.

Deae-Eddine Krim¹, Brendan Whelan², Mindy Harkness³, Karl Otto⁴, Billy W Loo⁵, Magdalena Bazalova-Carter¹

¹Physics and Astronomy, University of Victoria, Victoria V8P 5C2, Canada.

²Image-X Institute, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

³TibaRay, Inc., Fremont, CA, United States of America.

⁴Radformation, Inc., New York, NY, United States of America.

⁵Department of Radiation Oncology and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, United States of America.

PubMed DOI

Abstract

Objective.To develop and validate a treatment planning system (TPS) for a novel x-ray ultra-high dose rate (UHDR) system and compare its performance with conventional volumetric modulated arc therapy (VMAT).Approach.A TPS was developed for a novel x-ray UHDR system featuring stationary beamlines and a Scanning Pencil-beam High-speed Intensity-modulated x-ray source (SPHINX). We studied an exemplar…

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