Peer-Reviewed Publication
J Am Soc Echocardiogr2026;39(2):179-187.February 1, 2026Journal Article
Influence of Microbubble Properties and Carrier Frequency on Ultrasound Cavitation-Induced Flow Augmentation.
J Todd Belcik1, Aris Xie2, Yue Qie1, David Giraud3, Ruei-Jen Abraham-Fen2, Onur Varli4, Jeffry Powers5, Jonathan R Lindner6
1Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
2Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia.
3Applied Physics Laboratory, University of Washington, Seattle, Washington.
4Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia.
5Philips Ultrasound, Bothell, Washington.
6Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia. Electronic address: jlindner@virginia.edu.
Abstract
BACKGROUND: Cavitation of microbubble (MB) contrast agents produces shear-mediated vasodilation and an increase in tissue perfusion. These effects are mediated through endothelial and erythrocyte shear-sensitive pathways. Our aim was to determine whether augmentation of tissue perfusion produced by cavitation is influenced by the deformability of MBs, MB charge-mediated interaction with vascular c…
Create a free account to keep reading
Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.
Want unlimited research access? See Pro plans