Peer-Reviewed Publication
Stat Med2025;44(20-22):e70234.September 1, 2025Journal Article

What Is Fair? Defining Fairness in Machine Learning for Health.

Jianhui Gao1, Benson Chou1, Zachary R McCaw2, Hilary Thurston3, Paul Varghese4, Chuan Hong5, Jessica Gronsbell1,6,7
1Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.
2Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
3Department of Gender, Feminist & Women's Studies, York University, Toronto, Ontario, Canada.
4Verily Life Sciences, Cambridge, Massachusetts, USA.
5Department of Biostatistics, Duke University Raleigh, North Carolina, USA.
6Department of Family & Community Medicine, University of Toronto, Toronto, Ontario, Canada.
7Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.

Abstract

Ensuring that machine-learning (ML) models are safe, effective, and equitable across all patients is critical for clinical decision-making and for preventing the amplification of existing health disparities. In this work, we examine how fairness is conceptualized in ML for health, including why ML models may lead to unfair decisions and how fairness has been measured in diverse real-world applicat…

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