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Peer-Reviewed Publication
Radiology2025;316(2):e242594.August 1, 2025Journal Article

AI Should Read Mammograms Only When Confident: A Hybrid Breast Cancer Screening Reading Strategy.

Sarah D Verboom1, Jaap Kroes2, Santiago Pires2, Mireille J M Broeders3,4, Ioannis Sechopoulos1,4,5
1Radboud University Medical Center, Department of Medical Imaging, Geert Grooteplein Zuid 10, Nijmegen, 6525 GA, the Netherlands.
2ScreenPoint Medical BV, Nijmegen, the Netherlands.
3Radboud University Medical Center, IQ Health Science Department, Nijmegen, the Netherlands.
4Dutch Expert Centre for Screening (LRCB), Nijmegen, the Netherlands.
5University of Twente, Technical Medicine Center, Enschede, the Netherlands.

Abstract

Background Quantifying the uncertainty in artificial intelligence (AI)-based interpretations of mammograms could help AI integration in screening. Purpose To evaluate the reduction in radiologists' reading workload in mammographic screening while maintaining performance by incorporating an AI model that includes uncertainty quantification. Materials and Methods An AI model was introduced that outp…

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