Health AI Central
Peer-Reviewed Publication
Int Immunopharmacol2025;164115335.October 30, 2025Journal Article

3C3 alleviates atopic dermatitis-like phenotypes through cyclophilin A and B-mediated inhibition of calcineurin-NFAT pathway.

Yejin Jo1, Hayan Jeong1, Su-Jin Lee1, Jangho So1, Seung-Heon Yoo1, Soonnam Kim2, Suyoung Go2, Jee Yoon Shin3, Yul Lee4, Dong-Sik Shin4, Seok-In Kim5, Yoon-Sik Lee5, Bong-Gun Ju6
1Department of Life Science, Stress-Responding Biomaterial Center, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea.
2Kainos Medicine Inc, 700 Daewangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Republic of Korea.
3Genome Data Integration Centre, Syntekabio Inc., Daejeon, 34025, Republic of Korea.
4Department of Chemical and Biological Engineering, Sookmyung Women's University, Seoul 04310, Republic of Korea.
5BeadTech Inc. 10-dong 4th, 49 Wonsi-ro, Danwon-gu, Ansan-si, Gyeonggi-do 15610, Republic of Korea.
6Department of Life Science, Stress-Responding Biomaterial Center, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea. Electronic address: bgju@sogang.ac.kr.
PubMed DOI

Abstract

Atopic dermatitis (AD) disrupts a patients' quality of life and is associated with other atopic disorders, such as food allergy, allergic rhinitis, and asthma. Although topical medications are widely used, they have undesirable side effects, suggesting the need for treatments with improved efficacy and safety. In this study, we identified 3C3 as a candidate compound for AD treatment using in vitro…

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