Peer-Reviewed Publication
NPJ Dement2025;1(1):17.January 1, 2025Journal Article
Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index.
Somayeh Meysami1,2, Saurabh Garg3, Sam Hashemi3, Nasrin Akbari3, Ahmed Gouda3, Yosef Gavriel Chodakiewitz4, Thanh Duc Nguyen3, Rajpaul Attariwala5,6, Kellyann Niotis7,8,9, David A Merrill1,2,10, Cyrus A Raji11
1Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA USA.
2Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA USA.
3Prenuvo, Vancouver, BC Canada.
4Prenuvo, Los Angeles, CA USA.
5Voxelwise Imaging Technology, Vancouver, BC Canada.
6AIM Medical Imaging, Vancouver, BC Canada.
7Early Medical, Austin, TX USA.
8The Institute for Neurodegenerative Diseases-Florida, Boca Raton, FL USA.
9Preventive Neurology, New York, NY USA.
10Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA USA.
11Washington University in St Louis Mallinckrodt Institute, St. Louis, MO USA.
Abstract
Cigarette smoking is a risk factor for Alzheimer's and vascular dementia, but its impact on brain volume loss, a neurodegeneration biomarker on MRI, is unclear. In total, 10,134 participants from 4 sites were scanned with a whole-body 1.5 T MRI protocol with separate dedicated structural neuroimaging with 3D T1 MPRAGE sequences. Smokers versus non-smokers were compared by gray and white matter vol…
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