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EMBO Rep2025;26(17):4219-4247.September 1, 2025Journal Article

A pivot-tether model for nucleosome recognition by the chromosomal passenger complex.

Reinis R Ruza1, Chyi Wei Chung2, Danny B H Gold1, Michela Serena1,3, Emile Roberts2,4, Ulrike Gruneberg2, Francis A Barr5
1Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
2Department of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
3Arctoris Ltd, 120E Olympic Avenue Abingdon, OX14 4SA, Oxfordshire, UK.
4Biochemistry Department, University of Geneva, 30, Quai Ernest-Ansermet, 1205, Geneve, Switzerland.
5Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. francis.barr@bioch.ox.ac.uk.
PubMed PMC DOI PDF

Abstract

Spatial restriction of Aurora B to T3-phosphorylated histone H3 (H3pT3) nucleosomes adjacent to centromeres during prometaphase and metaphase enables it to phosphorylate proteins necessary for spindle assembly checkpoint signalling and biorientation of chromosomes on the mitotic spindle. Aurora B binding to H3pT3-nucleosomes requires a multivalent targeting module, the chromosomal passenger comple…

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