Peer-Reviewed Publication
PLoS One2025;20(6):e0326457.January 1, 2025Journal Article
Non-invasive tape sampling of tryptophan and kynurenine in relation to phenylalanine and tyrosine from melanoma and adjacent non-lesional skin: A pilot study.
Skaidre Jankovskaja1,2, Peter Spégel3, Kari Nielsen4,5, Sebastian Björklund1,2, Jeremy Bost6, Johan Engblom1,2, Gustav Christensen4,5, Oksana Rogova3, Maxim Morin1,2, Merete Haedersdal7,8, Martin Malmsten8, Chris D Anderson9, Tautgirdas Ruzgas1,2
1Department of Biomedical Science, Malmö University, Sweden.
2Biofilms Research Centre for Biointerfaces, Malmö University, Sweden.
3Centre for Analysis and Synthesis, Department of Chemistry, Lund University, Sweden.
4Department of Dermatology, Skåne University Hospital, Lund, Sweden.
5Department of Clinical Sciences Lund, Division of Dermatology and Venereology, Lund University, Lund, Sweden.
6SciBase AB, Sundbyberg, Sweden.
7Department of Dermatology, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark.
8Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
9Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Abstract
PURPOSE: To evade immunosurveillance many cancers convert tryptophan (Trp) into kynurenine (Kyn), which induces immunotolerance and suppresses immune responses. Elevated Kyn amounts have been found in blood from patients with cutaneous melanoma. This study aimed to investigate whether higher Kyn abundance and lower Trp abundance can be detected on the surface of cutaneous melanoma lesions compared…
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