Peer-Reviewed Publication
Eur J Heart Fail2025;27(8):1379-1392.August 1, 2025Journal Article
How to facilitate seamless translation from basic concepts to new heart failure drugs. A scientific statement of the Heart Failure Association of the ESC.
Carlo Gabriele Tocchetti1, Arantxa González2, Johannes Backs3,4,5,6, Piero Pollesello7, Peter P Rainer8,9, Gabriele Giacomo Schiattarella10,11,12,13, Milena Bellin14,15,16, Glenn Begley17, Ildiko Bock Marquette18, Jean-Luc Balligand19, Ines Falcao-Pires20, Rick Gorczynski21, Emilio Hirsch22, Jean-Sebastian Hulot23,24, Bert Klebl25, Alexander R Lyon26, Christoph Maack27,28, Timothy A McKinsey29, Oliver J Müller30, Ida Lunde31,32, Rusty Montgomery33, Giuseppe Vergaro34,35, Antoni Bayes-Genis36, Thomas Thum37,38,39, Peter van der Meer40, Linda Van Laake41, Franck Ruschitzka42, Petar Seferovic43, Andrew J Coats44, Marco Metra45, Giuseppe Rosano46,47, Sophie Van Linthout12,48, Rudolf A de Boer49
1Cardio-Pulmonary Onco-Immunology, Department of Translational Medical Sciences (DISMET), Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.
2Program of Cardiovascular Diseases, CIMA Universidad de Navarra, Department of Cardiology and Cardiac Surgery, Clínica Universidad de Navarra, and IdiSNA Pamplona, Spain; CIBERCV, Carlos III Institute of Health, Madrid, Spain.
3German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany.
4Institute of Experimental Cardiology, Medical Faculty Heidelberg, Heidelberg University, INF 669, Heidelberg, Germany.
5Internal Medicine VIII, Heidelberg University Hospital, INF 669, Heidelberg, Germany.
6Helmholtz Institute for Translational AngioCardioScience (HI-TAC), MDC at Heidelberg University, Heidelberg, Germany.
7Critical Care, Orion Pharma, Espoo, Finland.
8Heart Failure Program, Division of Cardiology, University Heart Center, Medical University of Graz, Graz, Austria.
9BioTechMed Graz, Graz, Austria.
10Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
11Max Rubner Center for Cardiovascular Metabolic Renal Research (MCR), Charité - Universitätsmedizin Berlin, Berlin, Germany.
12German Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany.
13Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
14Department of Biology, University of Padova, Padua, Italy.
15Veneto Institute of Molecular Medicine, Paduaa, Italy.
16Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.
17Parthenon Therapeutics, Boston, MA, USA.
18Department of Biochemistry and Medical Chemistry, Szentagothai Research Centre, University of Pecs, Pecs, Hungary.
19Pole of Pharmacology and Therapeutics, Institut de Recherche Experimentale et Clinique (IREC) and Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCLouvain), Brussels, Belgium.
20UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal.
21Gilead Sciences Inc., Foster City, CA, USA.
22Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Turin, Italy.
23Paris Cardiovascular Research Center, INSERM 970, Paris, France.
24Centre d'Investigation Clinique 1418, Hôpital Européen Georges-Pompidou, AP-HP, Paris, France.
25Lead Discovery Center GmbH, Dortmund, Germany.
26Cardio-Oncology Service, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK.
27Department of Translational Research, Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.
28Medical Clinic I, University Hospital Würzburg, Würzburg, Germany.
29Department of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
30Department of Internal Medicine V, University Hospital Schleswig-Holstein, University of Kiel and German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Kiel, Germany.
31Oslo Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevaal, Oslo, Norway.
32KG Jebsen Center for Cardiac Biomarkers, Campus Ahus, University of Oslo, Oslo, Norway.
33BioAge Labs, Richmond, CA, USA.
34Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
35Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
36Heart Institute, Hospital Unbiversitari Germasn Trias i Pujol, Universitat Autonoma de Barcelona, CIBERCV, Badalona, Spain.
37Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
38Fraunhofer Cluster of Excellence Immune-Mediated Diseases (CIMD), Hannover, Germany.
39Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
40Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
41Division Heart and Lungs, Department of Cardiology and Regenerative Medicine Center, University Medical Center Utrecht, Utrecht, The Netherlands.
42Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Heart Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
43Faculty of Medicine and Heart Failure Center, University of Belgrade, Belgrade University Medical Center, Belgrade, Serbia.
44Heart Research Institute, Sydney, NSW, Australia.
45Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
46Department of Human Sciences and Promotion of Quality of Life, San Raffaele Open University of Rome, Rome, Italy.
47Cardiology, San Raffaele Cassino Hospital, Cassino, Italy.
48Berlin Institute of Health (BIH) at Charité - Universitätmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany.
49Department of Cardiology, Erasmus MC, Cardiovascular Institute, Thorax Center, Rotterdam, The Netherlands.
Abstract
A rift has opened and is widening between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and preventive strategies. This problem involving the 'translation' of basic scientific findings into clinical applications and potential treatments or biomarkers for a condition like heart failure is widely recognized both in academia and industry. D…
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