Monte Carlo simulation of a novel medical linac concept for highly conformal x-ray FLASH cancer radiotherapy.

Deae-Eddine Krim¹, Brendan Whelan², Mindy Harkness³, Karl Otto⁴, Billy W Loo⁵, Magdalena Bazalova-Carter⁶

¹Physics and Astronomy, University of Victoria, Victoria, V8P 5C2, Canada. deaeeddinek@uvic.ca.

²Image-X Institute, School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

³TibaRay, Inc., Fremont, CA, USA.

⁴Radformation, Inc., New York, NY, USA.

⁵Department of Radiation Oncology and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

⁶Physics and Astronomy, University of Victoria, Victoria, V8P 5C2, Canada.

PubMed PMC DOI PDF

Abstract

A growing body of pre-clinical research has demonstrated the potential of ultra-high dose-rate (UHDR) radiotherapy to reduce normal tissue toxicity while maintaining tumor control. However, owing to a wide range of technical difficulties, no existing x-ray systems are capable of highly conformal UHDR radiotherapy to humans. In this work, we designed and simulated a novel x-ray UHDR system represen…

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