Are deeper sections and immunohistochemistry useful in detecting micrometastases and isolated tumour cells in colorectal cancer?

David W Dodington¹, Keegan Guidolin², Fayez Quereshy³, Runjan Chetty⁴, Stefano Serra⁵, Klaudia M Nowak⁵

¹Laboratory Medicine Program, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, ON, Canada. Electronic address: david.dodington@uhn.ca.

²Department of Surgery, University of Toronto, ON, Canada; Institute of Biomedical Engineering, University of Toronto, ON, Canada.

³Department of Surgery, University of Toronto, ON, Canada; Department of Surgery, University Health Network, Toronto, ON Canada.

⁴Deciphex, Dublin, Ireland.

⁵Laboratory Medicine Program, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, ON, Canada.

PubMed DOI

Abstract

Identification of lymph node metastases is critical for staging of colorectal cancer. Lymph node metastases are classified based on size as macrometastases, micrometastases, or isolated tumour cells (ITCs). Micrometastases are associated with worse prognosis; however, optimal detection methods have yet to be established. The first objective was to determine if deeper levels and immunohistochemistr…

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